Drug interactions
Demeclocycline + Methoxsalen
Severity: Major
Demeclocycline and Methoxsalen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Demeclocycline is among the more phototoxic tetracyclines, and methoxsalen with UVA greatly increases photosensitivity. The combination can cause severe sunburn-like reactions.
What this interaction means in plain words
Demeclocycline and Methoxsalen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive phototoxic effects of two photosensitizing drugs.
What to do
Avoid the combination if possible, or use an alternative antibiotic. If unavoidable, enforce strict photoprotection and consider lower UVA doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Methoxsalen Moderate
Frequently asked questions
Can I take Demeclocycline with Methoxsalen?
MediHelp rates the interaction as major. Demeclocycline and Methoxsalen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Demeclocycline is among the more phototoxic tetracyclines, and methoxsalen with UVA greatly increases photosensitivity. The combination can cause severe sunburn-like reactions.
How serious is the interaction between Demeclocycline and Methoxsalen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or use an alternative antibiotic. If unavoidable, enforce strict photoprotection and consider lower UVA doses.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Fedratinib, Pirfenidone. The full list is on the Methoxsalen page.
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