Drug interactions
Bendroflumethiazide + Oxaprozin
Severity: Moderate
Bendroflumethiazide and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and antihypertensive effects of thiazides and may cause sodium retention and renal impairment. The combination also increases the risk of acute kidney injury, particularly in older or volume-depleted patients.
What this interaction means in plain words
Bendroflumethiazide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis by oxaprozin causes sodium and water retention and reduces renal perfusion, opposing thiazide effects.
What to do
Monitor blood pressure, fluid status, renal function and electrolytes, especially at the start of therapy. Use the lowest effective NSAID dose for the shortest time and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Bendroflumethiazide with Oxaprozin?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the diuretic and antihypertensive effects of thiazides and may cause sodium retention and renal impairment. The combination also increases the risk of acute kidney injury, particularly in older or volume-depleted patients.
How serious is the interaction between Bendroflumethiazide and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, renal function and electrolytes, especially at the start of therapy. Use the lowest effective NSAID dose for the shortest time and ensure adequate hydration.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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