Drug interactions
Bendroflumethiazide + Probenecid
Severity: Moderate
Bendroflumethiazide and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can raise serum uric acid and compete for tubular secretion, which may oppose the uricosuric effect of probenecid. Probenecid may also raise thiazide levels slightly.
What this interaction means in plain words
Bendroflumethiazide and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal organic anion secretion, plus thiazide-induced hyperuricemia, counteracts probenecid's uricosuric action.
What to do
Monitor serum uric acid and gout control, and increase the probenecid dose or choose a non-thiazide antihypertensive if urate control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Bendroflumethiazide with Probenecid?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides can raise serum uric acid and compete for tubular secretion, which may oppose the uricosuric effect of probenecid. Probenecid may also raise thiazide levels slightly.
How serious is the interaction between Bendroflumethiazide and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout control, and increase the probenecid dose or choose a non-thiazide antihypertensive if urate control worsens.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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