Drug interactions
Bendroflumethiazide + Repaglinide
Severity: Moderate
Bendroflumethiazide and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce insulin secretion, which may counteract the effect of repaglinide. Loss of glycemic control is more likely at higher thiazide doses.
What this interaction means in plain words
Bendroflumethiazide and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced hypokalemia and impaired insulin release oppose the glucose-lowering action of repaglinide.
What to do
Monitor blood glucose and potassium when starting or adjusting the thiazide. Increase the antidiabetic dose if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Bendroflumethiazide with Repaglinide?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce insulin secretion, which may counteract the effect of repaglinide. Loss of glycemic control is more likely at higher thiazide doses.
How serious is the interaction between Bendroflumethiazide and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium when starting or adjusting the thiazide. Increase the antidiabetic dose if hyperglycemia develops.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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