Drug interactions
Bendroflumethiazide + Saxagliptin-metformin
Severity: Minor
Bendroflumethiazide and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose, particularly at higher doses, and may offset the effect of antidiabetic drugs. At low doses the effect is usually small.
What this interaction means in plain words
Bendroflumethiazide and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazides impair insulin secretion and glucose tolerance, partly through hypokalemia, opposing the effect of antidiabetic drugs.
What to do
Monitor blood glucose and potassium after starting or increasing the thiazide. Adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bendroflumethiazide and Saxagliptin-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Bendroflumethiazide with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Bendroflumethiazide and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose, particularly at higher doses, and may offset the effect of antidiabetic drugs. At low doses the effect is usually small.
How serious is the interaction between Bendroflumethiazide and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium after starting or increasing the thiazide. Adjust the antidiabetic regimen if control worsens.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
