Drug interactions
Bendroflumethiazide + Sitagliptin
Severity: Minor
Bendroflumethiazide and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose, particularly at higher doses, and may partly counteract sitagliptin. The effect is usually small at low doses.
What this interaction means in plain words
Bendroflumethiazide and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism, as thiazides can impair insulin secretion and sensitivity, partly through potassium depletion.
What to do
Monitor blood glucose and HbA1c when starting or increasing the thiazide. Maintain normal potassium levels and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Bendroflumethiazide with Sitagliptin?
MediHelp rates the interaction as minor. Bendroflumethiazide and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose, particularly at higher doses, and may partly counteract sitagliptin. The effect is usually small at low doses.
How serious is the interaction between Bendroflumethiazide and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting or increasing the thiazide. Maintain normal potassium levels and adjust antidiabetic therapy if needed.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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