Drug interactions
Bendroflumethiazide + Tolazamide
Severity: Moderate
Bendroflumethiazide and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce the effectiveness of sulfonylureas such as tolazamide. The effect is dose related and is usually modest at low doses.
What this interaction means in plain words
Bendroflumethiazide and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism, with thiazide-induced hypokalemia reducing insulin secretion and increasing insulin resistance.
What to do
Monitor blood glucose and potassium when a thiazide is started or its dose changed. Increase the antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Bendroflumethiazide with Tolazamide?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce the effectiveness of sulfonylureas such as tolazamide. The effect is dose related and is usually modest at low doses.
How serious is the interaction between Bendroflumethiazide and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium when a thiazide is started or its dose changed. Increase the antidiabetic therapy if control worsens.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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