Drug interactions
Benperidol + Brompheniramine
Severity: Moderate
Benperidol and Brompheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, and brompheniramine may increase drowsiness and anticholinergic effects when taken with the butyrophenone antipsychotic benperidol. Psychomotor impairment may result.
What this interaction means in plain words
Benperidol and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from H1 blockade and dopamine receptor antagonism.
What to do
Monitor for oversedation and anticholinergic effects, and counsel on driving. Prefer a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Benperidol with Brompheniramine?
MediHelp rates the interaction as moderate. Benperidol and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, and brompheniramine may increase drowsiness and anticholinergic effects when taken with the butyrophenone antipsychotic benperidol. Psychomotor impairment may result.
How serious is the interaction between Benperidol and Brompheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, and counsel on driving. Prefer a non-sedating antihistamine.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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