Drug interactions
Benperidol + Chlorpheniramine
Severity: Moderate
Benperidol and Chlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and benperidol is a potent antipsychotic, so the combination may increase drowsiness and impair psychomotor function. Additive anticholinergic effects are also possible.
What this interaction means in plain words
Benperidol and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Monitor for sedation and anticholinergic effects. Prefer a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Benperidol with Chlorpheniramine?
MediHelp rates the interaction as moderate. Benperidol and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and benperidol is a potent antipsychotic, so the combination may increase drowsiness and impair psychomotor function. Additive anticholinergic effects are also possible.
How serious is the interaction between Benperidol and Chlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic effects. Prefer a non-sedating antihistamine.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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