Drug interactions
Benperidol + Chlorzoxazone
Severity: Moderate
Benperidol and Chlorzoxazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent antipsychotic with sedative effects, and combined use with chlorzoxazone may increase drowsiness and impaired coordination.
What this interaction means in plain words
Benperidol and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Monitor for oversedation and use the lowest effective doses. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Benperidol with Chlorzoxazone?
MediHelp rates the interaction as moderate. Benperidol and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent antipsychotic with sedative effects, and combined use with chlorzoxazone may increase drowsiness and impaired coordination.
How serious is the interaction between Benperidol and Chlorzoxazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and use the lowest effective doses. Advise patients to avoid driving and alcohol.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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