Drug interactions
Benperidol + Desipramine
Severity: Moderate
Benperidol and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and each can cause hypotension and QT prolongation. Together they increase the likelihood of oversedation and may increase arrhythmia risk.
What this interaction means in plain words
Benperidol and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible additive QT effects.
What to do
Monitor sedation and orthostatic blood pressure and consider an ECG in patients with cardiac risk factors. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Benperidol with Desipramine?
MediHelp rates the interaction as moderate. Benperidol and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and each can cause hypotension and QT prolongation. Together they increase the likelihood of oversedation and may increase arrhythmia risk.
How serious is the interaction between Benperidol and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure and consider an ECG in patients with cardiac risk factors. Use the lowest effective doses.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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