Drug interactions
Benperidol + Maprotiline
Severity: Moderate
Benperidol and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and each can affect cardiac conduction and lower seizure threshold. Together they may cause oversedation, hypotension and QT-related risk.
What this interaction means in plain words
Benperidol and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible additive QT prolongation and reduced seizure threshold.
What to do
Monitor sedation and blood pressure, and obtain an ECG if cardiac risk factors exist. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Benperidol with Maprotiline?
MediHelp rates the interaction as moderate. Benperidol and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and each can affect cardiac conduction and lower seizure threshold. Together they may cause oversedation, hypotension and QT-related risk.
How serious is the interaction between Benperidol and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, and obtain an ECG if cardiac risk factors exist. Use the lowest effective doses.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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