Drug interactions
Benperidol + Methocarbamol
Severity: Moderate
Benperidol and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, so together they may lead to increased sedation and psychomotor impairment. Benperidol may also cause hypotension and extrapyramidal effects.
What this interaction means in plain words
Benperidol and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression between methocarbamol and the butyrophenone antipsychotic.
What to do
Monitor for oversedation and falls, and use lower starting doses. Counsel patients against driving if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Frequently asked questions
Can I take Benperidol with Methocarbamol?
MediHelp rates the interaction as moderate. Benperidol and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, so together they may lead to increased sedation and psychomotor impairment. Benperidol may also cause hypotension and extrapyramidal effects.
How serious is the interaction between Benperidol and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and falls, and use lower starting doses. Counsel patients against driving if drowsy.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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