Drug interactions
Benzhydrocodone / acetaminophen + Brexpiprazole
Severity: Major
Benzhydrocodone / acetaminophen and Brexpiprazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole combined with an opioid such as benzhydrocodone can produce additive sedation, dizziness and impaired psychomotor performance. Opioid-related respiratory depression may be worsened by other CNS depressants.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Brexpiprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system depression from opioid agonism and the antihistaminic and antiadrenergic effects of brexpiprazole.
What to do
Reserve the combination for patients in whom alternatives are inadequate, use the lowest effective doses for the shortest duration, and monitor for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Brexpiprazole?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Brexpiprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexpiprazole combined with an opioid such as benzhydrocodone can produce additive sedation, dizziness and impaired psychomotor performance. Opioid-related respiratory depression may be worsened by other CNS depressants.
How serious is the interaction between Benzhydrocodone / acetaminophen and Brexpiprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients in whom alternatives are inadequate, use the lowest effective doses for the shortest duration, and monitor for sedation and respiratory depression.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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