Drug interactions
Brexpiprazole + Buprenorphine buccal
Severity: Major
Brexpiprazole and Buprenorphine buccal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using brexpiprazole with buccal buprenorphine may cause additive drowsiness and slowed breathing. Cognitive and motor impairment can also be increased.
What this interaction means in plain words
Brexpiprazole and Buprenorphine buccal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression between an opioid partial agonist and a sedating antipsychotic.
What to do
Use only if alternatives are inadequate, keep doses low, and monitor for excessive sedation and respiratory depression, especially at initiation and after dose changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Buprenorphine buccal?
MediHelp rates the interaction as major. Brexpiprazole and Buprenorphine buccal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using brexpiprazole with buccal buprenorphine may cause additive drowsiness and slowed breathing. Cognitive and motor impairment can also be increased.
How serious is the interaction between Brexpiprazole and Buprenorphine buccal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if alternatives are inadequate, keep doses low, and monitor for excessive sedation and respiratory depression, especially at initiation and after dose changes.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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