Drug interactions
Benzhydrocodone / acetaminophen + Buspirone
Severity: Moderate
Benzhydrocodone / acetaminophen and Buspirone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buspirone may add to the sedation of opioids, though its respiratory depressant effect is limited. Opioid-related serotonergic effects are also possible, though less likely with benzhydrocodone.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Buspirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and sedation.
What to do
Use the lowest effective opioid dose and monitor for sedation and respiratory depression. Counsel patients about drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Buspirone?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Buspirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buspirone may add to the sedation of opioids, though its respiratory depressant effect is limited. Opioid-related serotonergic effects are also possible, though less likely with benzhydrocodone.
How serious is the interaction between Benzhydrocodone / acetaminophen and Buspirone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor for sedation and respiratory depression. Counsel patients about drowsiness and driving.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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