Drug interactions
Buprenorphine buccal + Chlorzoxazone
Severity: Major
Buprenorphine buccal and Chlorzoxazone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine with chlorzoxazone can intensify drowsiness and respiratory depression. Concurrent CNS depressants carry a labeled warning for profound sedation and respiratory compromise.
What this interaction means in plain words
Buprenorphine buccal and Chlorzoxazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression.
What to do
Use the lowest effective doses and monitor sedation and respiratory rate. Counsel patients to avoid alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Buprenorphine buccal with Chlorzoxazone?
MediHelp rates the interaction as major. Buprenorphine buccal and Chlorzoxazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Buprenorphine with chlorzoxazone can intensify drowsiness and respiratory depression. Concurrent CNS depressants carry a labeled warning for profound sedation and respiratory compromise.
How serious is the interaction between Buprenorphine buccal and Chlorzoxazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate. Counsel patients to avoid alcohol and driving.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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