Drug interactions
Benzhydrocodone / acetaminophen + Desflurane
Severity: Major
Benzhydrocodone / acetaminophen and Desflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzhydrocodone is an opioid prodrug of hydrocodone. Combining it with desflurane increases sedation, respiratory depression and hypotension.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Desflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression, with additive vasodilatory and hypotensive effects.
What to do
Titrate anesthetic and opioid doses to effect and monitor respiration, oxygen saturation and blood pressure. Continue monitoring after the procedure and use the lowest effective opioid dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desflurane
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Desflurane?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Desflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzhydrocodone is an opioid prodrug of hydrocodone. Combining it with desflurane increases sedation, respiratory depression and hypotension.
How serious is the interaction between Benzhydrocodone / acetaminophen and Desflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate anesthetic and opioid doses to effect and monitor respiration, oxygen saturation and blood pressure. Continue monitoring after the procedure and use the lowest effective opioid dose.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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