Drug interactions
Amisulpride + Desflurane
Severity: Major
Amisulpride and Desflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amisulpride causes dose-related QT prolongation and desflurane may add to this effect. Together they could increase the risk of torsades de pointes, particularly with electrolyte disturbances or bradycardia.
What this interaction means in plain words
Amisulpride and Desflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Desflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG throughout, and avoid low-dose intravenous amisulpride for nausea in patients with other QT risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desflurane
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Desflurane?
MediHelp rates the interaction as major. Amisulpride and Desflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amisulpride causes dose-related QT prolongation and desflurane may add to this effect. Together they could increase the risk of torsades de pointes, particularly with electrolyte disturbances or bradycardia.
How serious is the interaction between Amisulpride and Desflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG throughout, and avoid low-dose intravenous amisulpride for nausea in patients with other QT risk factors.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Anagrelide, Arsenic trioxide, Bedaquiline. The full list is on the Desflurane page.
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