Drug interactions
Anagrelide + Desflurane
Severity: Major
Anagrelide and Desflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide can prolong the QT interval and cause tachycardia, and desflurane may add to repolarization delay. The combination may increase the risk of ventricular arrhythmias.
What this interaction means in plain words
Anagrelide and Desflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Desflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Perform a baseline ECG and correct electrolytes before anesthesia. Monitor the ECG during the procedure and consider an alternative anesthetic in patients with known QT prolongation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desflurane
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Desflurane?
MediHelp rates the interaction as major. Anagrelide and Desflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Anagrelide can prolong the QT interval and cause tachycardia, and desflurane may add to repolarization delay. The combination may increase the risk of ventricular arrhythmias.
How serious is the interaction between Anagrelide and Desflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a baseline ECG and correct electrolytes before anesthesia. Monitor the ECG during the procedure and consider an alternative anesthetic in patients with known QT prolongation.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Arsenic trioxide, Bedaquiline. The full list is on the Desflurane page.
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