Drug interactions
Benzhydrocodone / acetaminophen + Levetiracetam
Severity: Moderate
Benzhydrocodone / acetaminophen and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids cause sedation and respiratory depression, and levetiracetam adds somnolence and dizziness. Concurrent use may increase drowsiness and impair alertness. Respiratory depression is mainly attributable to the opioid.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from the opioid and levetiracetam.
What to do
Use the lowest effective opioid dose and monitor sedation and respiratory status, especially when starting or increasing doses. Counsel against alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Levetiracetam?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids cause sedation and respiratory depression, and levetiracetam adds somnolence and dizziness. Concurrent use may increase drowsiness and impair alertness. Respiratory depression is mainly attributable to the opioid.
How serious is the interaction between Benzhydrocodone / acetaminophen and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor sedation and respiratory status, especially when starting or increasing doses. Counsel against alcohol and driving.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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