Drug interactions
Benzhydrocodone / acetaminophen + Linezolid
Severity: Major
Benzhydrocodone / acetaminophen and Linezolid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzhydrocodone is a prodrug of hydrocodone, and opioids given with MAO inhibitors can cause serotonin syndrome or opioid toxicity such as respiratory depression and coma. Labeling advises against use during or within 14 days of MAOI therapy, and linezolid is covered by this warning.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition by linezolid combined with opioid serotonergic activity and potentiation of opioid CNS effects.
What to do
Avoid the combination and use a non-opioid analgesic during linezolid therapy when possible. If an opioid is essential, start with small titrated doses and monitor blood pressure, mental status and respiration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Linezolid?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzhydrocodone is a prodrug of hydrocodone, and opioids given with MAO inhibitors can cause serotonin syndrome or opioid toxicity such as respiratory depression and coma. Labeling advises against use during or within 14 days of MAOI therapy, and linezolid is covered by this warning.
How serious is the interaction between Benzhydrocodone / acetaminophen and Linezolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-opioid analgesic during linezolid therapy when possible. If an opioid is essential, start with small titrated doses and monitor blood pressure, mental status and respiration.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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