Drug interactions
Benzhydrocodone / acetaminophen + Mifepristone
Severity: Major
Benzhydrocodone / acetaminophen and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and can raise hydrocodone concentrations derived from benzhydrocodone. This can lead to profound sedation and potentially fatal respiratory depression.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition decreases clearance of hydrocodone, increasing opioid exposure.
What to do
Avoid if possible, or use the lowest effective opioid dose with close monitoring for respiratory depression and sedation. Reduce the dose if the interacting drug is started, and reassess if mifepristone is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Mifepristone?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone inhibits CYP3A4 and can raise hydrocodone concentrations derived from benzhydrocodone. This can lead to profound sedation and potentially fatal respiratory depression.
How serious is the interaction between Benzhydrocodone / acetaminophen and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or use the lowest effective opioid dose with close monitoring for respiratory depression and sedation. Reduce the dose if the interacting drug is started, and reassess if mifepristone is stopped.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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