Drug interactions
Benzhydrocodone / acetaminophen + Procarbazine
Severity: Major
Benzhydrocodone / acetaminophen and Procarbazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine's MAO inhibiting activity may precipitate serotonin syndrome or opioid toxicity with benzhydrocodone, a hydrocodone prodrug. Reactions include agitation, hyperthermia, respiratory depression, hypotension and coma.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition increases serotonergic activity and may potentiate opioid CNS and respiratory depression.
What to do
Avoid the combination during procarbazine therapy and for 14 days after discontinuation. If an opioid is unavoidable, use small, carefully titrated doses and monitor blood pressure, respiration and signs of serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Procarbazine?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procarbazine's MAO inhibiting activity may precipitate serotonin syndrome or opioid toxicity with benzhydrocodone, a hydrocodone prodrug. Reactions include agitation, hyperthermia, respiratory depression, hypotension and coma.
How serious is the interaction between Benzhydrocodone / acetaminophen and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination during procarbazine therapy and for 14 days after discontinuation. If an opioid is unavoidable, use small, carefully titrated doses and monitor blood pressure, respiration and signs of serotonin toxicity.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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