Drug interactions
Benzhydrocodone / acetaminophen + Propafenone
Severity: Moderate
Benzhydrocodone / acetaminophen and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone inhibits CYP2D6, which converts hydrocodone to the more potent hydromorphone, so analgesic effect may be reduced. Hydrocodone itself is cleared by CYP3A4 and levels could rise if that pathway is also affected, with a risk of opioid adverse effects. Overall effects are variable.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Propafenone inhibits CYP2D6, reducing formation of hydromorphone from hydrocodone and altering opioid exposure.
What to do
Monitor for reduced analgesia and for sedation or respiratory depression. Adjust the opioid dose or choose a non-CYP2D6-dependent analgesic if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Benzhydrocodone / acetaminophen and Propafenone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Propafenone?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone inhibits CYP2D6, which converts hydrocodone to the more potent hydromorphone, so analgesic effect may be reduced. Hydrocodone itself is cleared by CYP3A4 and levels could rise if that pathway is also affected, with a risk of opioid adverse effects. Overall effects are variable.
How serious is the interaction between Benzhydrocodone / acetaminophen and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced analgesia and for sedation or respiratory depression. Adjust the opioid dose or choose a non-CYP2D6-dependent analgesic if needed.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
