Drug interactions
Dofetilide + Propafenone
Severity: Contraindicated
Dofetilide and Propafenone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs affect cardiac repolarization and conduction. Used together they can cause excessive QT prolongation and torsades de pointes, and propafenone may also affect dofetilide handling.
What this interaction means in plain words
Dofetilide and Propafenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Propafenone belongs to Cardiovascular.
Why it happens
Additive effects on cardiac repolarization and QT prolongation, with possible pharmacokinetic effects.
What to do
Avoid concurrent use. Allow adequate washout of one antiarrhythmic before starting the other, under ECG monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Propafenone
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
- Propafenone + Ritonavir Contraindicated
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Propafenone?
MediHelp rates the interaction as contraindicated. Dofetilide and Propafenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs affect cardiac repolarization and conduction. Used together they can cause excessive QT prolongation and torsades de pointes, and propafenone may also affect dofetilide handling.
How serious is the interaction between Dofetilide and Propafenone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Allow adequate washout of one antiarrhythmic before starting the other, under ECG monitoring.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dronedarone, Nilotinib, Nirmatrelvir / ritonavir. The full list is on the Propafenone page.
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