Drug interactions
Nilotinib + Propafenone
Severity: Contraindicated
Nilotinib and Propafenone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib carries a boxed warning for QT prolongation and sudden death, and propafenone adds proarrhythmic effects. Nilotinib also inhibits CYP3A4 and CYP2D6, which may increase propafenone concentrations and further raise the risk of arrhythmia.
What this interaction means in plain words
Nilotinib and Propafenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nilotinib belongs to Oncology; Propafenone belongs to Cardiovascular.
Why it happens
Additive QT prolongation combined with nilotinib inhibition of CYP3A4 and CYP2D6, increasing propafenone exposure.
What to do
Avoid the combination and choose a non-QT-prolonging alternative for rhythm control. If nilotinib cannot be replaced, switch propafenone to an agent without QT or CYP interactions.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
- Propafenone + Ritonavir Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Propafenone?
MediHelp rates the interaction as contraindicated. Nilotinib and Propafenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nilotinib carries a boxed warning for QT prolongation and sudden death, and propafenone adds proarrhythmic effects. Nilotinib also inhibits CYP3A4 and CYP2D6, which may increase propafenone concentrations and further raise the risk of arrhythmia.
How serious is the interaction between Nilotinib and Propafenone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging alternative for rhythm control. If nilotinib cannot be replaced, switch propafenone to an agent without QT or CYP interactions.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nirmatrelvir / ritonavir. The full list is on the Propafenone page.
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