Drug interactions
Benzhydrocodone / acetaminophen + Ramelteon
Severity: Moderate
Benzhydrocodone / acetaminophen and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon can cause somnolence and dizziness, which may add to opioid sedation. The risk of respiratory depression from ramelteon is low compared with benzodiazepines or sedative-hypnotics.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression between a melatonin receptor agonist and an opioid.
What to do
Use the lowest effective opioid dose and monitor for sedation and respiratory depression, especially at initiation or dose increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Ramelteon?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ramelteon can cause somnolence and dizziness, which may add to opioid sedation. The risk of respiratory depression from ramelteon is low compared with benzodiazepines or sedative-hypnotics.
How serious is the interaction between Benzhydrocodone / acetaminophen and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor for sedation and respiratory depression, especially at initiation or dose increases.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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