Drug interactions
Benzhydrocodone / acetaminophen + Sertraline
Severity: Moderate
Benzhydrocodone / acetaminophen and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline combined with hydrocodone prodrugs may cause serotonin syndrome, and sertraline's mild CYP2D6 inhibition may alter hydrocodone activation. Opioid-related sedation and respiratory depression are also a concern.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity and weak CYP2D6 inhibition affecting hydrocodone metabolism.
What to do
Use the lowest effective opioid dose and monitor for agitation, tremor, hyperthermia, sedation and respiratory depression. Educate the patient on symptoms of serotonin syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Sertraline?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline combined with hydrocodone prodrugs may cause serotonin syndrome, and sertraline's mild CYP2D6 inhibition may alter hydrocodone activation. Opioid-related sedation and respiratory depression are also a concern.
How serious is the interaction between Benzhydrocodone / acetaminophen and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor for agitation, tremor, hyperthermia, sedation and respiratory depression. Educate the patient on symptoms of serotonin syndrome.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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