Drug interactions
Benzhydrocodone / acetaminophen + Warfarin
Severity: Moderate
Benzhydrocodone / acetaminophen and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The acetaminophen component can raise INR with regular use, increasing bleeding risk in warfarin-treated patients. The effect depends on dose and duration.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Acetaminophen metabolite NAPQI is thought to inhibit vitamin K-dependent clotting factor synthesis, potentiating warfarin.
What to do
Check INR within a few days of regular use and adjust the warfarin dose as needed. Keep acetaminophen to the lowest effective dose and shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Warfarin?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The acetaminophen component can raise INR with regular use, increasing bleeding risk in warfarin-treated patients. The effect depends on dose and duration.
How serious is the interaction between Benzhydrocodone / acetaminophen and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR within a few days of regular use and adjust the warfarin dose as needed. Keep acetaminophen to the lowest effective dose and shortest duration.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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