Drug interactions
Benzhydrocodone / acetaminophen + Ziprasidone
Severity: Major
Benzhydrocodone / acetaminophen and Ziprasidone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzhydrocodone is an opioid prodrug of hydrocodone, and combining it with ziprasidone can cause additive sedation, hypotension and respiratory depression. Severe cases may lead to coma or death.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression (pharmacodynamic synergism).
What to do
Reserve the combination for patients without alternatives, use the lowest effective doses for the shortest time, and monitor for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Ziprasidone?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzhydrocodone is an opioid prodrug of hydrocodone, and combining it with ziprasidone can cause additive sedation, hypotension and respiratory depression. Severe cases may lead to coma or death.
How serious is the interaction between Benzhydrocodone / acetaminophen and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients without alternatives, use the lowest effective doses for the shortest time, and monitor for sedation and respiratory depression.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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