Drug interactions
Benzphetamine + Desipramine
Severity: Moderate
Benzphetamine and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic anorectic, and tricyclic antidepressants can alter the response to such agents. The combination may increase blood pressure, heart rate and arrhythmia risk, or unpredictably change the effect of benzphetamine.
What this interaction means in plain words
Benzphetamine and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclics block norepinephrine reuptake and the neuronal uptake of indirect sympathomimetics, producing unpredictable pressor responses.
What to do
Monitor blood pressure and heart rate, particularly at the start of therapy or after dose changes. Consider an alternative weight-management approach in patients with cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Benzphetamine with Desipramine?
MediHelp rates the interaction as moderate. Benzphetamine and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzphetamine is a sympathomimetic anorectic, and tricyclic antidepressants can alter the response to such agents. The combination may increase blood pressure, heart rate and arrhythmia risk, or unpredictably change the effect of benzphetamine.
How serious is the interaction between Benzphetamine and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, particularly at the start of therapy or after dose changes. Consider an alternative weight-management approach in patients with cardiovascular disease.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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