Drug interactions
Benzphetamine + Oxytocin
Severity: Moderate
Benzphetamine and Oxytocin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxytocin can cause hypotension or, with rapid infusion, vasopressor-related fluctuations, and sympathomimetic anorectics like benzphetamine raise blood pressure and heart rate. Together, blood pressure and cardiovascular effects may be unpredictable during labor or postpartum use.
What this interaction means in plain words
Benzphetamine and Oxytocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive or opposing hemodynamic effects of oxytocin and a sympathomimetic amine; no established pharmacokinetic mechanism.
What to do
Monitor blood pressure and heart rate closely when oxytocin is given to a patient taking benzphetamine. Consider withholding the anorectic around delivery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxytocin
- Carboprost tromethamine + Oxytocin Major
- Dinoprostone + Oxytocin Major
- Ephedrine + Oxytocin Major
- Fexinidazole + Oxytocin Major
- Givinostat + Oxytocin Major
- Misoprostol + Oxytocin Major
Frequently asked questions
Can I take Benzphetamine with Oxytocin?
MediHelp rates the interaction as moderate. Benzphetamine and Oxytocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxytocin can cause hypotension or, with rapid infusion, vasopressor-related fluctuations, and sympathomimetic anorectics like benzphetamine raise blood pressure and heart rate. Together, blood pressure and cardiovascular effects may be unpredictable during labor or postpartum use.
How serious is the interaction between Benzphetamine and Oxytocin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely when oxytocin is given to a patient taking benzphetamine. Consider withholding the anorectic around delivery.
What other medicines interact with Oxytocin?
MediHelp also lists interactions of Oxytocin with, for example, Carboprost tromethamine, Dinoprostone, Ephedrine. The full list is on the Oxytocin page.
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