Drug interactions
Benzphetamine + Ziprasidone
Severity: Moderate
Benzphetamine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic stimulant, and ziprasidone is sedating, so the effects are partly opposing and unpredictable. Stimulants can also worsen psychosis, and both drugs may affect heart rate and rhythm.
What this interaction means in plain words
Benzphetamine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic CNS effects; stimulant dopaminergic and adrenergic activity may counter antipsychotic effect.
What to do
Monitor psychiatric status and heart rate and blood pressure. Avoid in patients with unstable psychosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Benzphetamine with Ziprasidone?
MediHelp rates the interaction as moderate. Benzphetamine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzphetamine is a sympathomimetic stimulant, and ziprasidone is sedating, so the effects are partly opposing and unpredictable. Stimulants can also worsen psychosis, and both drugs may affect heart rate and rhythm.
How serious is the interaction between Benzphetamine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric status and heart rate and blood pressure. Avoid in patients with unstable psychosis.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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