Drug interactions
Benztropine + Cyclizine
Severity: Moderate
Benztropine and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine has significant antimuscarinic activity that adds to that of benztropine. This may cause dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older patients.
What this interaction means in plain words
Benztropine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benztropine belongs to Central Nervous System; Cyclizine belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic effects such as cognitive changes and urinary retention. Consider a non-anticholinergic antiemetic such as ondansetron.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benztropine
- Benztropine + Memantine-donepezil Major
- Abobotulinumtoxina + Benztropine Moderate
- Amantadine + Benztropine Moderate
- Amitriptyline + Benztropine Moderate
- Amoxapine + Benztropine Moderate
- Atropine iv / + Benztropine Moderate
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Benztropine with Cyclizine?
MediHelp rates the interaction as moderate. Benztropine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine has significant antimuscarinic activity that adds to that of benztropine. This may cause dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older patients.
How serious is the interaction between Benztropine and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as cognitive changes and urinary retention. Consider a non-anticholinergic antiemetic such as ondansetron.
What other medicines interact with Benztropine?
MediHelp also lists interactions of Benztropine with, for example, Memantine-donepezil, Abobotulinumtoxina, Amantadine. The full list is on the Benztropine page.
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