Drug interactions
Benztropine + Maprotiline
Severity: Moderate
Benztropine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so combined use may cause marked dry mouth, constipation, urinary retention, blurred vision and confusion. Older patients and those with glaucoma are especially vulnerable.
What this interaction means in plain words
Benztropine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benztropine belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic toxicity and cognitive effects. Use the lowest effective doses or choose a less anticholinergic antidepressant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Benztropine
- Benztropine + Memantine-donepezil Major
- Abobotulinumtoxina + Benztropine Moderate
- Amantadine + Benztropine Moderate
- Amitriptyline + Benztropine Moderate
- Amoxapine + Benztropine Moderate
- Atropine iv / + Benztropine Moderate
Frequently asked questions
Can I take Benztropine with Maprotiline?
MediHelp rates the interaction as moderate. Benztropine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combined use may cause marked dry mouth, constipation, urinary retention, blurred vision and confusion. Older patients and those with glaucoma are especially vulnerable.
How serious is the interaction between Benztropine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and cognitive effects. Use the lowest effective doses or choose a less anticholinergic antidepressant.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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