Drug interactions
Benztropine + Tranylcypromine
Severity: Moderate
Benztropine and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benztropine has anticholinergic effects that can combine with those of MAO inhibitors, causing confusion, tachycardia, urinary retention, constipation and, in rare cases, hyperpyrexia. Severe reactions are described in labeling for anti-parkinsonian drugs.
What this interaction means in plain words
Benztropine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benztropine belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive anticholinergic and autonomic effects with MAO inhibition.
What to do
Use the lowest effective benztropine dose and monitor for anticholinergic toxicity, agitation and temperature rise. Stop benztropine if severe symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Benztropine
- Benztropine + Memantine-donepezil Major
- Abobotulinumtoxina + Benztropine Moderate
- Amantadine + Benztropine Moderate
- Amitriptyline + Benztropine Moderate
- Amoxapine + Benztropine Moderate
- Atropine iv / + Benztropine Moderate
Frequently asked questions
Can I take Benztropine with Tranylcypromine?
MediHelp rates the interaction as moderate. Benztropine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benztropine has anticholinergic effects that can combine with those of MAO inhibitors, causing confusion, tachycardia, urinary retention, constipation and, in rare cases, hyperpyrexia. Severe reactions are described in labeling for anti-parkinsonian drugs.
How serious is the interaction between Benztropine and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective benztropine dose and monitor for anticholinergic toxicity, agitation and temperature rise. Stop benztropine if severe symptoms develop.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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