Drug interactions
Berotralstat + Cyclosporin
Severity: Moderate
Berotralstat and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and CYP3A4, so it can increase cyclosporine exposure and the risk of nephrotoxicity. Cyclosporine, a BCRP and P-gp inhibitor, may also raise berotralstat levels and its gastrointestinal and QT-related adverse effects.
What this interaction means in plain words
Berotralstat and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Cyclosporin belongs to Miscellaneous.
Why it happens
Berotralstat inhibits P-gp and CYP3A4 affecting cyclosporine, while cyclosporine inhibits BCRP and P-gp affecting berotralstat.
What to do
Monitor cyclosporine trough concentrations and renal function after starting or stopping berotralstat, and adjust the cyclosporine dose. Watch for berotralstat adverse effects including gastrointestinal symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Cyclosporin?
MediHelp rates the interaction as moderate. Berotralstat and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-glycoprotein and CYP3A4, so it can increase cyclosporine exposure and the risk of nephrotoxicity. Cyclosporine, a BCRP and P-gp inhibitor, may also raise berotralstat levels and its gastrointestinal and QT-related adverse effects.
How serious is the interaction between Berotralstat and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations and renal function after starting or stopping berotralstat, and adjust the cyclosporine dose. Watch for berotralstat adverse effects including gastrointestinal symptoms.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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