Drug interactions
Berotralstat + Dexamethasone
Severity: Minor
Berotralstat and Dexamethasone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and dexamethasone is a P-gp substrate, so systemic dexamethasone exposure may rise modestly. This could increase corticosteroid adverse effects during prolonged therapy.
What this interaction means in plain words
Berotralstat and Dexamethasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Berotralstat belongs to Miscellaneous; Dexamethasone belongs to Endocrine.
Why it happens
Inhibition of P-glycoprotein efflux by berotralstat, reducing dexamethasone efflux and clearance.
What to do
No routine dose change is needed for short courses; monitor for corticosteroid adverse effects such as hyperglycemia and fluid retention with long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Dexamethasone?
MediHelp rates the interaction as minor. Berotralstat and Dexamethasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Berotralstat inhibits P-glycoprotein and dexamethasone is a P-gp substrate, so systemic dexamethasone exposure may rise modestly. This could increase corticosteroid adverse effects during prolonged therapy.
How serious is the interaction between Berotralstat and Dexamethasone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for short courses; monitor for corticosteroid adverse effects such as hyperglycemia and fluid retention with long-term use.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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