Drug interactions
Berotralstat + Erythromycin
Severity: Moderate
Berotralstat and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a P-glycoprotein inhibitor and can raise berotralstat exposure. Berotralstat in turn inhibits P-gp and may increase exposure to P-gp substrates. Higher berotralstat levels raise the risk of gastrointestinal effects and QT prolongation.
What this interaction means in plain words
Berotralstat and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Erythromycin belongs to Anti Bacterial.
Why it happens
Mutual P-glycoprotein inhibition reduces efflux of berotralstat and may raise erythromycin levels.
What to do
Monitor for berotralstat adverse effects such as gastrointestinal upset and consider ECG monitoring if QT risk factors exist. Consider an alternative antibiotic if prolonged therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Erythromycin?
MediHelp rates the interaction as moderate. Berotralstat and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin is a P-glycoprotein inhibitor and can raise berotralstat exposure. Berotralstat in turn inhibits P-gp and may increase exposure to P-gp substrates. Higher berotralstat levels raise the risk of gastrointestinal effects and QT prolongation.
How serious is the interaction between Berotralstat and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for berotralstat adverse effects such as gastrointestinal upset and consider ECG monitoring if QT risk factors exist. Consider an alternative antibiotic if prolonged therapy is needed.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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