Drug interactions
Berotralstat + Irinotecan
Severity: Moderate
Berotralstat and Irinotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and may raise irinotecan exposure. This could increase the risk of diarrhea and neutropenia.
What this interaction means in plain words
Berotralstat and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Irinotecan belongs to Oncology.
Why it happens
Berotralstat inhibits P-gp, reducing efflux of irinotecan and its metabolites.
What to do
Monitor for severe diarrhea and neutropenia, and reduce the irinotecan dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Irinotecan?
MediHelp rates the interaction as moderate. Berotralstat and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-glycoprotein and may raise irinotecan exposure. This could increase the risk of diarrhea and neutropenia.
How serious is the interaction between Berotralstat and Irinotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for severe diarrhea and neutropenia, and reduce the irinotecan dose if toxicity develops.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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