Drug interactions
Berotralstat + Ketoconazole
Severity: Moderate
Berotralstat and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole increases berotralstat exposure, raising the risk of gastrointestinal effects and QT prolongation. Berotralstat labeling advises reducing the dose with P-gp or BCRP inhibitors.
What this interaction means in plain words
Berotralstat and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole inhibits P-glycoprotein and BCRP transporters, increasing berotralstat absorption and exposure.
What to do
Reduce the berotralstat dose to the labeled lower dose when coadministered and monitor for gastrointestinal symptoms and QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Ketoconazole?
MediHelp rates the interaction as moderate. Berotralstat and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole increases berotralstat exposure, raising the risk of gastrointestinal effects and QT prolongation. Berotralstat labeling advises reducing the dose with P-gp or BCRP inhibitors.
How serious is the interaction between Berotralstat and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the berotralstat dose to the labeled lower dose when coadministered and monitor for gastrointestinal symptoms and QT prolongation.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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