Drug interactions
Berotralstat + Lorlatinib
Severity: Moderate
Berotralstat and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat is a P-glycoprotein substrate, and lorlatinib may induce P-gp. Reduced berotralstat exposure may weaken prophylaxis against hereditary angioedema attacks.
What this interaction means in plain words
Berotralstat and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induction of P-glycoprotein efflux decreases berotralstat absorption and exposure.
What to do
Monitor angioedema attack frequency and consider an alternative prophylactic agent if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Lorlatinib?
MediHelp rates the interaction as moderate. Berotralstat and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat is a P-glycoprotein substrate, and lorlatinib may induce P-gp. Reduced berotralstat exposure may weaken prophylaxis against hereditary angioedema attacks.
How serious is the interaction between Berotralstat and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor angioedema attack frequency and consider an alternative prophylactic agent if control worsens.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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