Drug interactions
Berotralstat + Pantoprazole
Severity: Minor
Berotralstat and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pantoprazole has been reported to inhibit BCRP in vitro, and berotralstat is a BCRP substrate, so berotralstat exposure could rise modestly. The clinical significance is uncertain.
What this interaction means in plain words
Berotralstat and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Berotralstat belongs to Miscellaneous; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Possible inhibition of intestinal BCRP efflux by pantoprazole, raising berotralstat absorption.
What to do
No dose change is usually needed. Monitor for berotralstat adverse effects such as gastrointestinal upset and QT-related symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Pantoprazole?
MediHelp rates the interaction as minor. Berotralstat and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pantoprazole has been reported to inhibit BCRP in vitro, and berotralstat is a BCRP substrate, so berotralstat exposure could rise modestly. The clinical significance is uncertain.
How serious is the interaction between Berotralstat and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for berotralstat adverse effects such as gastrointestinal upset and QT-related symptoms.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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