Drug interactions
Berotralstat + Pazopanib
Severity: Moderate
Berotralstat and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and may raise pazopanib concentrations, as pazopanib is a P-gp substrate. This could increase pazopanib toxicities such as hepatotoxicity and hypertension.
What this interaction means in plain words
Berotralstat and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Pazopanib belongs to Oncology.
Why it happens
Inhibition of P-gp efflux (and BCRP) by berotralstat increases pazopanib absorption.
What to do
Monitor liver enzymes and blood pressure more closely during combined use. Lower the pazopanib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Pazopanib?
MediHelp rates the interaction as moderate. Berotralstat and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-glycoprotein and may raise pazopanib concentrations, as pazopanib is a P-gp substrate. This could increase pazopanib toxicities such as hepatotoxicity and hypertension.
How serious is the interaction between Berotralstat and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and blood pressure more closely during combined use. Lower the pazopanib dose if toxicity develops.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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