Drug interactions
Berotralstat + Safinamide
Severity: Minor
Berotralstat and Safinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide may inhibit BCRP, a transporter for berotralstat. Berotralstat exposure could rise, increasing gastrointestinal and other adverse effects.
What this interaction means in plain words
Berotralstat and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Berotralstat belongs to Miscellaneous; Safinamide belongs to Central Nervous System.
Why it happens
Inhibition of BCRP efflux increases berotralstat absorption.
What to do
Monitor for berotralstat adverse effects such as gastrointestinal upset and QT-related symptoms. Reduce the dose or stop if tolerability is poor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Safinamide?
MediHelp rates the interaction as minor. Berotralstat and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Safinamide may inhibit BCRP, a transporter for berotralstat. Berotralstat exposure could rise, increasing gastrointestinal and other adverse effects.
How serious is the interaction between Berotralstat and Safinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for berotralstat adverse effects such as gastrointestinal upset and QT-related symptoms. Reduce the dose or stop if tolerability is poor.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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