Drug interactions
Berotralstat + Vincristine
Severity: Moderate
Berotralstat and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and may raise vincristine exposure. Higher vincristine levels can worsen neurotoxicity, constipation and myelosuppression.
What this interaction means in plain words
Berotralstat and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Vincristine belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux, and possibly CYP3A4, reducing vincristine clearance.
What to do
Monitor for neuropathy, constipation and ileus, and check blood counts. Consider vincristine dose reduction or an alternative to berotralstat if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Vincristine?
MediHelp rates the interaction as moderate. Berotralstat and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-glycoprotein and may raise vincristine exposure. Higher vincristine levels can worsen neurotoxicity, constipation and myelosuppression.
How serious is the interaction between Berotralstat and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, constipation and ileus, and check blood counts. Consider vincristine dose reduction or an alternative to berotralstat if toxicity appears.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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