Drug interactions
Betamethasone + Cyclosporin
Severity: Moderate
Betamethasone and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids and cyclosporine can affect each other's concentrations, and cyclosporine may increase steroid exposure. This may increase steroid adverse effects or alter immunosuppression, and both drugs add to infection risk.
What this interaction means in plain words
Betamethasone and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betamethasone belongs to Endocrine; Cyclosporin belongs to Miscellaneous.
Why it happens
Interplay at CYP3A4 and possibly P-glycoprotein, with additive immunosuppression.
What to do
Monitor cyclosporine trough levels and for steroid adverse effects such as hyperglycemia and infection, adjusting doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Betamethasone
Frequently asked questions
Can I take Betamethasone with Cyclosporin?
MediHelp rates the interaction as moderate. Betamethasone and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids and cyclosporine can affect each other's concentrations, and cyclosporine may increase steroid exposure. This may increase steroid adverse effects or alter immunosuppression, and both drugs add to infection risk.
How serious is the interaction between Betamethasone and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and for steroid adverse effects such as hyperglycemia and infection, adjusting doses as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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