Drug interactions
Betaxolol + Candesartan-hydrochlorothiazide
Severity: Moderate
Betaxolol and Candesartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Betaxolol with an ARB and a thiazide produces additive blood pressure reduction and may cause bradycardia or hypotension. This combination is often used deliberately, but it requires monitoring.
What this interaction means in plain words
Betaxolol and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Candesartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through beta-blockade, angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure, heart rate and serum potassium when starting or titrating. Avoid use during pregnancy because of the ARB.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Candesartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Betaxolol and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Betaxolol with an ARB and a thiazide produces additive blood pressure reduction and may cause bradycardia or hypotension. This combination is often used deliberately, but it requires monitoring.
How serious is the interaction between Betaxolol and Candesartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium when starting or titrating. Avoid use during pregnancy because of the ARB.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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