Drug interactions
Betaxolol + Hydrochlorothiazide-losartan
Severity: Minor
Betaxolol and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Betaxolol and losartan/hydrochlorothiazide have additive blood pressure lowering effects, which is often intended but can cause hypotension or bradycardia. Potassium effects are mixed, and losartan carries fetal toxicity if used in pregnancy regardless of the beta-blocker.
What this interaction means in plain words
Betaxolol and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Betaxolol belongs to Cardiovascular; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamic effects, with opposing small effects on serum potassium.
What to do
Monitor blood pressure, heart rate and serum potassium when starting or adjusting doses. Avoid in pregnancy because of losartan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Betaxolol and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Betaxolol and losartan/hydrochlorothiazide have additive blood pressure lowering effects, which is often intended but can cause hypotension or bradycardia. Potassium effects are mixed, and losartan carries fetal toxicity if used in pregnancy regardless of the beta-blocker.
How serious is the interaction between Betaxolol and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium when starting or adjusting doses. Avoid in pregnancy because of losartan.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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